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Transylvania... Lupin has been captured and hanged to death; the coroner's report confirms that down to the DNA level this was the real Lupin the Third. However, Zenigata refuses to believe Lupin is dead and drives to a castle to view the body. He then proceeds to drive a stake through the heart of Lupin's corpse. The corpse explodes, and Zenigata comes face to face with... Lupin?!
Lupin is surprised by this turn of events but has no time to chat with Zenigata. He is off to Egypt to retrieve the "Philosopher's Stone" from the pharaoh's pyramid. Fujiko has promised to exchange a date with her for the stone. Lupin succeeds in his theft but is double-crossed by Fujiko. As Fujiko hands over the stone to her mysterious employer, she finds out that Lupin has double-crossed her by handing over a fake stone containing a transmitter.
Fujiko's employer is Mamo, a man obsessed with immortality. What follows is a wild chase through Paris, the Caribbean, and Colombia to discover Mamo's secret. Is Mamo immortal as he claims? Is Lupin even the real Lupin?